Conducting a randomised trial during an influenza pandemic: an example of a trial set up and ‘hibernated’ ready to activate and recruit within 4 weeks
نویسندگان
چکیده
Background No randomised controlled trial has been successfully conducted during an influenza pandemic. The ASAP trial (Adjuvant Steroids in Adults with Pandemic Influenza) aims to use the novel strategy of set-up in advance of an influenza pandemic, and ‘hibernation’ in readiness for activation in a pandemic. Upon activation, the trial needs to recruit the first participant within 4 weeks, and to complete recruitment of 2200 participants within the first pandemic wave of approximately 6 weeks.
منابع مشابه
Randomised trials during a public health crisis, such as pandemic flu: a case study for a model of ‘off the shelf' ready-to-go trials
Background During the 2009 influenza pandemic NIHR funded a successful portfolio of studies. Nevertheless, the challenges of planning and conducting research during a pandemic were considerable. Clearly, advance planning would potentially have considerable advantages in terms of speed, efficiency and relevance of the research. In 2011 the NIHR issued a themed call for pandemic flu research. Of ...
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